Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG

Nature, Published online: 26 August 2026; doi:10.1038/s41586-026-10927-4Cryogenic electron microscopy structures of full-length human UGCG, the gatekeeper that dictates the scale and composition of glycosphingolipid diversity, are reported, showing that it uses a metal-independent catalytic mechanism driven by an arginine network.